Variation of the Fourier Transform Mass Spectra Phase Function with Experimental Parameters
| Type: | Application |
Scientific Paper |
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| Number: | Technology |
DOI: 10.1021/ac2017585 |
FTMS |
| Year | Products |
2011 |
solariX 12T FTICR |
| Author | |
Yulin Qi, Mark P. Barrow, Steve L. Van Orden, Christopher J. Thompson, Huilin Li, Pilar Perez-Hurtado, and Peter B. O'Connor |
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| Reference | |
Analytical Chemistry |
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Abstract |
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It has been known for almost 40 years that phase correction of FT-ICR data can generate an absorption-mode spectrum with much improved peak shape compared to the conventional magnitude-mode. However, research on phasing has been slow due to the complexity of phase-wrapping problem. Recently, the method for phasing a broadband FT-ICR spectrum has been solved in the MS community which will surely resurrect this old topic. This paper provides a discussion on the data processing procedure of phase correction and features of the phase function based on both a mathematic treatment and experimental data. Finally, it is shown that the same phase function can be optimized by adding correction factors, and applied from one experiment to another with different instrument parameters, regardless of the sample measured. Thus, in the vast majority of cases, the phase function needs to be calculated just once, whenever the instrument is calibrated.
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