Absorption-mode: The Next Generation of Fourier Transform Mass Spectra
| Type: | Application |
Scientific Paper |
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| Number: | Technology |
DOI: 10.1021/ac3000122 |
FTMS |
| Year | Products |
2012 |
solariX 12T FTICR |
| Author | |
Yulin Qi, Mark P. Barrow, Huilin Li, Joseph E Meier, Steve L. Van Orden, Christpher J. Thompson, and Peter B O'Connor |
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| Reference | |
Analytical Chemistry |
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Abstract |
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The Fourier transform spectrum can be presented in the absorption-mode (common used in FT-NMR), magnitude-mode (FT-ICR), and the power-mode (engineering applications). As is routinely used in FT-NMR, it is well known that the absorption-mode display gives a much narrower peak shape which greatly improves the spectrum; recently, the successful solution of the phase equation allowed broadband phase correction which makes it possible to apply the absorption-mode routinely in FT-ICR. With the empirical evidence provided herein, it has been confirmed that in addition to the improvement on resolving power, compared to the conventional magnitude-mode, the new absorption-mode improves the S/N of a spectrum by 1.4 fold and can improve the mass accuracy up to 2 fold with no extra cost in instrumentation. Therefore, it is worthwhile to apply and promote the absorption-mode in routine FT-ICR experiments.
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